11 Celiac Disease Symptoms You Need to Pay Attention To

Updated: Sep. 27, 2019

The symptoms of a gluten allergy are so subtle that many cases are missed. Here’s how your body might signal that you urgently need to a gluten-free diet.

Female doctor talking to an elderly patient

What is celiac disease?

Approximately 3 million Americans have celiac disease, according to The University of Chicago Medicine Celiac Center. It’s a condition in which the gluten in food triggers an immune response that damages the small intestine, which affects its ability to absorb nutrients. While the disease is common, it’s shockingly underdiagnosed because celiac disease affects each person differently. “Celiac disease symptoms may come on gradually or they may appear suddenly and dramatically,” explains Peter H.R. Green, MD, director of the Celiac Disease Center at Columbia University, in his book Celiac Disease: A Hidden Epidemic. “They may also wax and wane over a long period of time.” Compounding the diagnostic challenge is the fact that there are six “silent” or asymptomatic cases of celiac for each symptomatic one. Still, since celiac disease puts you at risk for a host of long-term complications, it’s important to get diagnosed and treated—especially because a delay in treatment increases your chances of developing another autoimmune disorder (scarily, most patients have symptoms for nine years before they’re diagnosed). There are more than 200 signs of celiac disease, but it’s most common to have one or more of the following symptoms.

man in pajamas sitting on the edge of a bed and holding his stomach in pain

Bouts of diarrhea

The “classic” celiac disease symptoms may be intestinal problems, but only about one-third of adults with the disease actually experience diarrhea (it’s more common in children because their digestive tracts are shorter and they have less area to compensate for tissue damage). When diarrhea occurs, it tends to show up as stools that are a bit looser (versus very watery stools) and more frequent than usual. It also tends to be a recurring problem. There is a myriad of causes of diarrhea: prolonged inflammation of the intestine; poor absorption of dietary sugars and fat, which draw so much water into the colon that the stool remains liquid; lactose intolerance, which results when damage to the intestine destroys the enzymes that digest milk products; and bacterial overgrowth. It’s unclear why, but people with celiac disease have more bacteria in their small intestine than usual, says Dr. Green. Read up on effective home remedies for diarrhea.

woman wincing in pain with her hands crossed on her stomach
iStock/Eva Katalin Kondoros

Flatulence, bloating, and pain

The excess bacteria in the intestine feed on the poorly absorbed nutrients, releasing gas and causing distention, cramps, and increased flatulence. The same malabsorbed nutrients are also responsible for foul-smelling and bulky, greasy stools. If you find yourself battling the bloat regularly, these habits can reduce bloating.

elderly man holding his hand against his chest

Frequent heartburn

People with celiac disease are more likely to suffer from heartburn. The Gluten-Free Society recommends being steadfast with a gluten-free diet to combat heartburn and acid reflux. These natural remedies relieve heartburn.

red pills in blister packaging

Unexplained anemia

Anemia in celiac disease can be caused by multiple factors, including deficiency in iron, folate (a B vitamin), and vitamin B12, as well as chronic inflammation. “People suffering from persistent anemia, especially iron-deficiency anemia, where other underlying medical conditions have been ruled out, should ask their doctors about testing for celiac disease,” says Dr. Green. These are the silent signs of anemia you shouldn’t ignore.

tired man rubbing his eyes


Fatigue is one of the major celiac disease symptoms. It’s also seen in numerous other medical conditions, which is why many doctors often look elsewhere for a diagnosis. But “extreme fatigue has a true physiological basis as one of the major side effects of celiac disease,” says Dr. Green, who points to malnutrition and the malabsorption of nutrients and intestinal inflammation. Here are other medical reasons you could be tired all the time.

closeup of clasped elderly hands

Arthritis and joint pain

People who are sensitive to gluten can have symptoms anywhere in the body when partially digested gluten fragments leak from the intestine into the bloodstream, explains Dr. Green. This can cause serious problems outside the gut, including joint pain. Since having one autoimmune disease increases the likelihood of having another, rheumatoid arthritis, type 1 diabetes, and other autoimmune disorders should be considered red flags that alert doctors to test for celiac disease. If you’re exploring a gluten-free diet, consider these hidden dangers to be aware of before you make permanent changes.

brunette woman with brown eyes holding a glass of milk
iStock/Antonio Diaz

Bone loss or osteoporosis

Osteoporosis, a condition in which bones become weak and brittle, is a complication of untreated celiac disease. The small intestine is responsible for absorbing important nutrients, including calcium, which is essential for building and maintaining healthy bones, says Dr. Green. Even people with celiac disease who consume enough calcium are often deficient in this nutrient. Because calcium is needed to keep bones healthy, low bone density is common with celiac—the prevalence of osteoporosis and osteopenia (lower than normal bone density) in newly diagnosed patients may be as high as 75 percent. These are signs you could have osteoporosis and not know it.

man in a white shirt scratching his forearm

Itchy rash

Dermatitis herpetiformis (DH) is an intensely itchy, blistering rash that can occur anywhere on the body. Most patients scratch the itchy skin until it breaks or bleeds, so it often looks like a rash with scratches, says Dr. Green, who notes that the physical blisters, continual scratching, and loss of sleep take a psychological toll on many patients. Symptoms tend to come and go and the condition is often mistaken for other conditions, such as eczema or herpes, says Jeffrey Weinberg, MD, associate clinical professor of dermatology at Mount Sinai Hospital and a spokesperson for the American Academy of Dermatology. DH affects up to 25 percent of people with celiac who typically have no digestive symptoms. But since some of these patients will suffer from many of the same malabsorption problems as those who don’t have DH, they still may require treatment from specialists other than the diagnosing dermatologist. These are other surprising diseases dermatologists find first.

man massaging his thumb joint

Tingling numbness in the hands and feet

Ten percent of people with celiac suffer from an associated neurological condition, usually peripheral neuropathy (nerve damage that causes numbness, tingling, pricking sensations, or muscle weakness) or ataxia, which impacts the central nervous system and is characterized by jerky, uncoordinated movements, and gait, according to The Foundation for Peripheral Neuropathy. The upshot: People with neuropathy of an unknown cause should be tested for celiac disease.

Asian woman holding her temples and wincing


Migraines are one of the lesser-known celiac disease symptoms. According to Beyond Celiac, an awareness and advocacy group for the condition, migraine sufferers are at higher risk of having celiac disease than the rest of the population. More studies are needed to learn the intricacies of the correlation, but it’s suspected it may be that the inflammation caused by celiac affects the whole body, including the brain. These are other common reasons you could have a migraine.

Doctor consulting with a couple

Infertility issues

The research isn’t conclusive, but a number of studies suggest a higher prevalence of undiagnosed celiac disease in women who had trouble conceiving—from 2 to 6 percent, compared to 1 percent in the general population. In a study published in the Journal of Clinical Gastroenterology, researchers found that women with infertility had 3.5 times higher odds of having celiac disease compared to those who did not have the same problems. Reports also suggest an association between celiac disease and gyno issues like endometriosis and missed periods. These are the conditions you might be mistaking for gluten intolerance.

Reader's Digest
Originally Published in Reader's Digest